Medical and scientific disclaimer

Educational simulation only

AyFlux illustrates acyclovir and valacyclovir pharmacokinetic models under selected assumptions about administration, kidney function, and renal replacement therapy. It is not medical advice or a clinically validated dosing, diagnosis, monitoring, or treatment tool.

Do not use AyFlux to prescribe or change medication, diagnose acyclovir toxicity, evaluate an individual patient's safety, modify dialysis, or make emergency or patient-care decisions. Follow official product labeling, validated clinical guidance, and qualified professional judgment instead.

What the concentration curves represent

Plasma, cerebrospinal fluid (CSF), and CMMG values shown by AyFlux are model predictions, not direct patient measurements. The calculations depend on assumed drug distribution, absorption, renal clearance, CSF transfer, metabolite formation, and dialysis parameters. Those assumptions may not apply to an individual patient.

Displayed reference concentrations, antiviral susceptibility values, and reported toxicity associations do not define a safe dose, establish effective treatment, or diagnose toxicity in a specific person.

Uncertainty and validation

Monte Carlo intervals and other uncertainty displays describe variation under a selected set of model assumptions. A displayed 90% interval does not establish 90% clinical predictive accuracy or coverage. Fitting to selected published summary values is not independent patient-level validation.

Hemodialysis, peritoneal dialysis, and CRRT scenarios are simplified and may differ substantially from real treatments, where machine settings, solute clearance, fluid exchange, residual renal function, and patient physiology vary.

Methods and source code

See the methods and limitations guide and the open-source implementation for model assumptions. AyFlux is intended for learning and exploratory research illustration, not individualized clinical decision support.