Plasma sampling and parameter recovery
Three sampling schedules use subsets of the same six simulated plasma concentrations. Select a synthetic adult to compare estimated peak concentration, exposure and total systemic clearance after one IV infusion.
Lines show pointwise posterior medians. Circles show the six simulated measurements. The 12-hour sample represents a pre-dose trough for an assumed 12-hour interval.
| Sampling schedule | Peak (mg/L) | AUC₀–₁₆ (mg·h/L) | Clearance (L/h) |
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Experimental design
Each 70 kg adult receives 700 mg of IV acyclovir over one hour at a creatinine clearance of 95 mL/min without dialysis. Measurements at 0.5, 1, 2, 4, 8 and 12 hours include simulated Gaussian assay error (5% CV with a minimum SD of 0.1 mg/L).
The fit reweights 441 candidate pairs of clearance and central-volume scale factors. Metabolite formation clearance and other model parameters are fixed. Each example uses the first noise realization for its parameter pair in the seeded recovery experiment. Interval widths describe parameter uncertainty within this model and grid.
Reproducible methods and source code